Pamamycin: a new antibiotic and stimulator of aerial mycelia formation.
نویسندگان
چکیده
Pamamycin is a new antibiotic isolated from Streptomyces alboniger ATCC 12461. The antibiotic is active in vitro against Gram-positive bacteria, Neurospora, and Mycobacteria. The compound also acts as a streptomycete differentiation effector. It stimulates aerial mycelia formation in the producing organism. The new antibiotic of elemental composition C36H63NO7 is completely different from puromycin, also produced by this strain. The present communication deals with the isolation, properties, and preliminary characterization of pamamycin.
منابع مشابه
Isolation, physico-chemical properties and biological activity of pamamycin-607, an aerial mycelium-inducing substance from Streptomyces alboniger.
Pamamycin-607, which showed aerial mycelium-inducing activity, has been isolated from Streptomyces alboniger IFO 12738. At 0.1 microgram/disc it induces aerial mycelia in the aerial mycelium-negative strain of S. alboniger but inhibits growth of the substrate mycelia at 10 micrograms/disc. It also acts as an antibiotic against some fungi and bacteria. When KMnO4 was partitioned with pamamycin-6...
متن کاملRelationship between response to and production of the aerial mycelium-inducing substances pamamycin-607 and A-factor.
Respectively, exogenous pamamycin-607 and A-factor restored or stimulated aerial mycelium formation in 30 (67%) and 6 (13%) of 45 Streptomyces strains, and both restored or stimulated it in 5 strains (11%). Pamamycin-607 production was detected in 3 of those strains that responded to pamamycin-607. These findings indicate that pamamycin-607 acts on the common regulatory system for aerial myceli...
متن کاملA New Genus of the Order Actinomycetales
The morphological, cu1ωral, physiologicai and blochemical characteristics of a new actinomycete strain producing a new antibiotic, setamycin are described. The strain forms aerial mycelia. There is no fragmentation of vegetative mycelia. Since the cell wall type is a new one containhlg both LL-and meso-2,6-diaminopimelic acid, glyclne and galactose, strain KM6054could not be classified in any p...
متن کاملStereoselective synthesis of pamamycin-607.
A macrodiolide antibiotic pamamycin-607 was synthesized by joining two hydroxy acid components. Three cis-2, 5-disubstituted tetrahydrofuran rings in the molecule were stereoselectively prepared by radical cyclization reactions of beta-alkoxyvinyl ketone intermediates and a beta-alkoxymethacrylate substrate. The key step of the synthesis is characterized by the predominant threo product formati...
متن کاملTotal synthesis of pamamycin-607.
Pamamycins are 16-membered macrodiolides isolated from Streptomyces alboniger and S. aurantiacus.1 They display autoregulatory, antibiotic, and anionophoric activities2 (Figure 1). Pamamycin-6071b-d is especially interesting for its potent activity2e against gram-positive bacteria (including multiple antibioticresistant strains of Mycobacterium tuberculosis) as well as against phytopathogenic f...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- The Journal of antibiotics
دوره 32 7 شماره
صفحات -
تاریخ انتشار 1979